WOJCIECH SIWEK, PhD
Hi, I am an assistant professor and a Marie Skłodowska-Curie fellow at the International Centre for Cancer Vaccine Science, University of Gdańsk (PL). I hold a master's degree in biotechnology from the University of Warsaw (PL) and a PhD in biochemistry from the International Institute of Molecular and Cell Biology in Warsaw (PL). After that, I trained at the Gulbenkian Institute (PT), University of Oxford (UK) and Harvard Medical School (USA). I specialize in biomedical research with a focus on gene regulation and epigenetics. I am fascinated by how cells remember previous environmental states. I am keen to translate this research into the clinic.
My professional core values are excellence and integrity with kindness, respect and an open mind.
get in touch!
LinkedIn: Wojciech Siwek
How cells remember?
Proper regulation of gene expression is fundamental for multicellular life. In my research, I am interested in how cells maintain gene expression states. I am exploring a phenomenon present in the innate immune system – transcriptional memory as a model system. Transcriptional memory is a process during which cells exposed to a certain cue (induction) will remember the experience and respond to the second stimulation with the same signal (reinduction) more strongly. I am studying how this process works in human cells.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 101025900
STAT1 IS REQUIRED TO ESTABLISH BUT NOT MAINTAIN INTERFERON-Y-INDUCED TRANSCRIPTIONAL MEMORY
ACTIVATION OF CLUSTERED IFNY TARGET GENES DRIVES COHESIN-CONTROLLED TRANSCRIPTIONAL MEMORY
CRYSTAL STRUCTURE AND DIRECTED EVOLUTION OF SPECIFICITY OF NLAIV RESTRICTION ENDONUCLEASE
Journal of Molecular Biology
TIME-CHIP: A METHOD TO DETERMINE LONG-TERM LOCUS-SPECIFIC NUCLEOSOME INHERITANCE
Methods in Molecular Biology
TYPE III CRISPR COMPLEXES FROM THERMUS THERMOPHILUS
Acta Biochimica Polonica
STRUCTURAL BASIS OF THE METHYLATION SPECIFICITY OF R.DPNI
Nucleic Acids Research
CRYSTAL STRUCTURE AND MECHANISM OF ACTION OF THE N6-METHYLADENINE-DEPENDENT TYPE IIM RESTRICTION ENDONUCLEASE R. DPNI
Nucleic Acids Research